While George is feeling emasculated because of the sisterly way Izzie and Meredith treat him, Izzie is assigned to a patient about to lose all of his masculinity. Meanwhile, Meredith continues to hide her mother's affliction, and Izzie deals with sexual harassment in the work place.
Dr Shepard deals with a man who has nails in his head.
Izzy gets a case where a man is left to lose his masculine parts.
The man with the nails survives.
Alex posts pictures of izzys modeling days all over.
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